集团简介

王博

发布人:时间:2020-09-05浏览:

王博、教授

办公地址:青岛市黄岛区前湾港路57951白菜资讯主站J2-211-1

电子邮箱:wb@sdust.edu.cn

联系电话: 13206485008

招生专业及研究方向

招生专业:

硕士生招生专业:化学工程与技术,材料化工(专硕)

博士生招生专业:化学工程与技术,矿物加工

研究方向:

硕士招生方向:绿色化学,药物中间体化学,不对称合成,手性药物中间体,生物催化.

博士生招生方向:绿色化学,药物中间体化学,不对称合成,手性药物中间体,生物催化。

个人经历

  1. 2019.12 ---- 现在,51白菜网教授博导。

  2. 2019.04 ---- 2019.11, 海南大学化学工程与技术学院教授博导。

  3. 2013.09 ---- 2019.03, 海南大学材料与51白菜网教授。

  4. 2011.10 ---- 2013.09, 瑞典皇家理工学院化学院生物技术学系博士后研究员。

  5. 2004.07 ---- 2005.07, 中国石化股份茂名分公司化工事业部干部。

  6. 2008.08 ---- 2011.09, 浙江大学51白菜网生物化工专业博士

  7. 2005.08 ---- 2008.06, 浙江工业大学药学院药物化学硕士。

  8. 2000.09 ---- 2004.07, 海南大学理工学院化学工程与工艺专业学士。

科研项目

  1. 51白菜资讯主站山海英才系列科研启动基金项目,350万元,2020.01 – 2024.12.

  2. 国家自然科学基金地区基金项目,2186801,一石三鸟的使用转氨酶和羰基还原酶的双酶催化体系研究,2019.01-2022.1248万元,在研,主持。

  3. 国家自然科学基金青年项目,21502036,单酶体系中转胺酶催化的反应平衡消除研究,2016.01-2018.1224.72万元,在研,主持。

  4. 国家重点研发计划项目,2017YFC1103800,磷酸钙纳米粉体及纳米多孔微球合成工程化技术研发, 2017.06 –2020.123200 万元,在研,参研(科研骨干9/41

  5. 国家自然科学基金面上项目,21176215,恶臭假单胞菌扁桃酸消旋酶催化底物多样性产生机制,2012.01-2015.1260 万元,已结题,参研。

  6. 海南省自然科学基金创新团队项目,2016CXTD006,高ee值生物手性胺的制备研究,2016.01-2017.1230万元,已结题,主持。

  7. 横向课题,S-2-胺基丁酰胺的化学-酶法制备技术开发,2015.01—2016.0525万元,在研,主持。

  8. 海南大学科研启动基金项目,kyqd1408,无催化剂条件下醛与胺缩合成酰胺的合成研究,2014.04-2016.0310万元,已结题,主持.

学术成就

一、Selected publications:

  1. Xinchun Jv, Shuting Sun, Qun Zhang, Muyao Du, Lan Wang, Bo Wang*, Efficient and Mild Reductive Amination of Carbonyl Compounds Catalysed by Dual-Function Palladium Nanoparticles, ACS Sustainable Chemistry & Engineering, 2020, 2020, 8 (3) , 1618-1626

  2. Yaxu Liu, Ziyi Quan, Shaopo He, Zexi Zhao, Jiang Wang, Bo Wang*, Heterogeneous palladium-based catalyst promoted reduction of oximes to amines: using H2 of 1 atm in H2O under mildconditions, React. Chem. Eng., 2019, 4, 1145-1152

  3. Yaxu Liu, Shaopo He, Ziyi Quan, Huizhuo Cai, Yang Zhao, Bo Wang,*Mild palladium-catalysed highly efficient hydrogenation of C≡N, C-NO2, and C=O bonds using H2 of 1 atm in H2O, Green Chem., 2019,21, 830-838

  4. HuihuiRen, Bo Wang,*etal., High-selective hydrogenation of aldehydes promoted by palladium-based catalyst and its application in equilibrium displacement in one-enzyme procedure using ω-transaminase, Org. Chem. Front., 2019,6, 1587-1593

  5. Kuan Zhang, Yi Wang, Tao Sun, Bo Wang,*Hongyu Zhang, Bioinspired Surface Functionalization for Improving Osteogenesis of Electrospun Polycaprolactone Nanofiber, Langmuir, Langmuir 2018, 34, 50, 15544-15550

  6. Jianhui Li, Shaopo He, Kuan Zhang, Ziyi Quan, Qiheng Shan, Zhongliang Sun, Bo Wang,* UV Assisted High-efficient Synthesis of α-Ketoamides Using Air Promoted by A Non-metal Catalyst in Aqueous SolutionChemCatChem2018, 10, 4868-4873.

  7. Yujia Cheng, Qiheng Shan, Yue Zhang, Ziyi Quan, Kuan Zhang, Bo Wang,*A highly efficient one-enzyme protocol using omega-transaminase and an amino donor enabling equilibrium displacement assisted by molecular oxygen, Organic Chemistry Frontiers, 2018, 5, 1633-1638.

  8. Jianhui Li, Shaopo He, Kuan Zhang, Ziyi Quan, Qiheng Shan, Zhongliang Sun, Bo Wang,* UV Assisted High-efficient Synthesis of α-Ketoamides Using Air Promoted by A Non-metal Catalyst in Aqueous SolutionChemCatChem2018, 10, 4781-4781.

  9. Yue Zhang, Yujia Cheng, Huizhuo Cai, Shaopo He, Qiheng Shan, Hongwei Zhao, Yiping Chen, Bo Wang,*Catalyst-free aerobic oxidation of aldehydesinto acids in water under mild conditions, Green Chemistry, 2017, 19, 5708-5713.

  10. Wang Bo, Land Henrik, and Berglund Per*, Efficient single-enzymatic cascade for asymmetric synthesis of chiral amines catalyzed by ω-transaminase, Chemical Communications, 2013, 49, 161-163.

  11. Wang Bo*, Liu Yanfeng, Zhang Dela, Feng Yuhong and Li Jiacheng, Efficient kinetic resolution of amino acid catalyzed by lipase AS ‘Amano’ via cleavage of amide bond, Tetrahedron: Asymmetry, 2012, 23, 1338-1342.

  12. Wang Bo, Jiang Ling, Wang Jue, Wang Dan, Liu Min and Yu Hongwei*, A tandem and fully enzymatic procedure for green resolution of chiral alcohol: acylation and deacylation in non-aqueous media, Tetrahedron: Asymmetry, 2011, 22, 980-985.

  13. Wang Bo, Tang Xiaoling, Ren Gangfeng, Liu Ji, and Yu Hongwei*, Escherichia coli BioH: an esterase with high activity and enantioselectivity for kinetic resolution of secondary alcohols in organic solvents. Tetrahedron Letters2010, 51, 6360-6364.

  14. Wang Bo, Liu Ji, Tang Xiaoling, Cheng Cheng, Gu Jiali, Dai Liyan*, Yu Hongwei*, Enzymatic synthesis of (S)-glutaric acid monoesters aided by molecular dockingTetrahedron Letters201051309-312.

  15. Wang Bo, Tang Xiaoling, Ren Gangfeng, Liu Ji, Yu Hongwei*, A new high-throughput screening method for determining active and enantioselective hydrolases, Biochemical Engineering Journal, 2009, 46, 345-349.

  16. Wang Bo*, Yu Chuan Ming, Chen Zhi Wei, Su Wei Ke, An efficient method for the synthesis of dialkylchlorophosphates from trialkyl phosphites using bis(trichloromethyl) carbonate, Chinese Chemical Letters, 2008, 19, 904-906.

  17. Wang DanZhang KuanJia LuhanZhang DantingZhang YueCheng YujiaLin ChangWang Bo*nBu4NI-mediated oxidation of methyl ketones to a-ketoamides: using ammonium-, primary/secondary amine-salt as amine moiety Organic & Biomolecular Chemistry, 2017,15, 3427-3434.

  18. Wang DanZhang KuanJia LuhanZhang DantingZhang YueCheng YujiaLin ChangWang Bo*Correction: nBu4NI-mediated oxidation of methyl ketones to a-ketoamides: using ammonium-, primary/secondary amine-salt as amine moiety Organic & Biomolecular Chemistry, 2017,15, 5095-5095.

  19. Fuyan Liu, Kuan Zhang,Yanfeng Liu,Shan Chen,Yiping Chen,Dela Zhang,Chunfu Lin, Bo Wang*, Solvent-free one-pot oxidation of ethylarenes forthe preparation of a-ketoamides under mildconditionsRSC Advances2017.1.3077158~7162

  20. Chen Shan, Liu Fuyan, Zhang Kuan, Huang Hansheng, Wang Huani, Gong Yiwei, Zhang Dela, Chen Yiping, Lin Chang, Wang Bo*, An efficient enzymatic aminolysis for kinetic resolution of aromatic alpha-hydroxyl acid in non-aqueous mediaTetrahedron Letters2016.11.305748):5312~5314

  21. Hongyin Yang, Wenjian Hu, Shengjue Deng, Tiantian Wu,Bo Wang*Catalyst-free amidation of aldehyde with amine under mild conditionsNew Journal of Chemistry2015, 398):5912~5915

  22. Jiang Ling, Wang Bo, Li Rongrong, Shen Sa, Yu Hongwei, Ye Lidan, Catalytic promiscuity ofEscherichia coliBioH esterase: Application in the synthesis of 3,4-dihydropyran derivatives, Process Biochemistry, 2014, 49, 1135–1138.

  23. Jiang Ling, Wang Bo, Li Rongrong, Shen Sa, Yu Hongwei, Ye Lidan, “Amano” lipase DF-catalyzed efficient synthesis of 2,2ʹ-arylmethylene dicyclohexane-1,3-dione

  24. derivatives in anhydrous media, Chinese Chemical Letters, 2014, 251190-1192.

  25. Tang Xiaoling, Liu Ji, Wang BoYu Hongwei*, Cloning, screening and characterization of enantioselective ester hydrolases from Escherichia coli K-12, World Journal of Microbiology and Biotechnology, 2011, 27, 129-136.

  26. Liu Ji, Tang Xiaoling, Wang Bo, Yu Hongwei*, Min Hang, Cloning, screening and characterization of ester hydrolases with enantioselectivity in typical bacteria, Process Biochemistry, 2010, 45, 475-480

  27. Wang Jue, Wang Dan, Wang Bo,Liu Ji, Mei Zhuohang and Yu Hongwei*, Enhanced activity of Rhizomucormiehei Lipase by directed evolution with simultaneous evolution of the propeptide. Applied Microbiology and Biotechnology,2012, 96, 443 -450.

  28. Wang Dan, Wang Jue, Wang Boand Yu Hongwei*, A New and Efficient Colorimetric High-throughput Screening Method for Triacylglycerol Lipase Directed Evolution, Journal of Molecular Catalysis B: Enzymatic, 2012, 82, 18-23.

  29. Yu Chuan-Ming*, Wang Bo, Chen Zhi-Wei, A Novel Synthesis of Alkylamino Substituted Methylenediphosphonates Using Bis(trichloromethyl) Carbonate and RCONR1R2, Chinese Journal of Chemistry, 2008, 26, 1899-1901.

二、会议论文

  1. Wang Bo, Land Henrik, and Berglund Per*, An efficient one-enzyme cascade for asymmetric synthesis of chiral amines catalyzed by ω-transaminase. 1st International Symposium on Transaminase Biocatalysis, KTH 2013, Stockholm, 2013, 2.28 -3.1.

  2. Wang Bo*,Yu Hongwei, A Fluorescent high-throughput screening method for determining active and enatioselectivehydrolysases. The International Symposium on Advanced Bio., Nano, and Pharmaceutical Science and Technology, Conference, Beijing, 2009, 5.3-5.6. 3.

  3. Mattias Anderson, Guangning Ma, Wang Bo, Henrik Land, Armando Córdova, Per Berglund, Synthesis of enantiomerically pure Υ-amino alcohols usingω-transaminase, 1st International Symposium on Transaminase Biocatalysis, KTH 2013, Stockholm, 2013, 2.28 -3.1

  4. Jiang Ling, Wang Bo, and Yu Hongwei, Biocatalytic promiscuous: Escherichia coli BioH esterase-catalysed aldol-and koevenagel reactions. The International Symposium on Exploring the Frontiers of Chemical & Biochemical Engineering, Conference, Beijing, 2012, 5.1-5.4.

  5. Chen, Yiping(*)Chen, ChenLiang, ZhenyiWang, BoLiu, PinghuaiInvestigation of Extraction and Purification Technology of Total Saponins from Sindoraglabra Seeds3rd International Conference on Material, Mechanical and Manufacturing Engineering (IC3ME),广州,2015.01.19-2015.01.20

论著专利

1、专著

  1. 王博,黎吉辉,有机合成反应原理及应用研究,原子能出版社,6010002015.03.16

  2. 李睿,徐晓强,王博,化工催化剂与催化技术研究,水利水电出版社,4010002014.1.1

2、授权发明专利

  1. 王博,一种长春质碱酒石酸盐的制备方法,2016.5.18,中国,CN201410761229.7

  2. 刘艳凤,王博,李嘉诚,周浩浩,韦卓勋,韦卓勋,一种由苯直接羟基化制备苯酚的方法,2016.09.17,中国,CN201510244495.7

  3. 王博,李永曙,梅丽琴,谭成侠,一种核苷化合物催化裂解方法,2012.12.12,中国,ZL200910154500.X

  4. 王博,李永曙,谭成侠,一种美洛西林钠溶媒结晶制备方法,2011.05.25,中国,ZL200910099044.3

  5. 于洪巍,王博,徐红娜,一种酶羟化3β-胆固醇乙酸酯制备7β-羟基-3β胆固醇乙酸酯的方法,2015.05.13,中国,ZL201010523507.7

  6. 于洪巍,王博,车大庆,酶法制备手性4-取代-26-二氧哌啶-35-二甲酸单酰胺类化合物的方法,2012.12.05,中国,ZL200910101041.9

  7. 于洪巍,王博,车大庆,酶催化制备(S)-3-取代戊二酸单酯类化合物的方法,2013.04.17,中国,ZL200910101394.9

  8. 于洪巍,王博,汤晓玲,刘击,消旋1-苯基乙醇类化合物的酶拆分方法,2012.10.31,中国,ZL200810162671.2

  9. 陈志卫,苏为科,丁锴,王博,邹振荣,钱振青,一种6,8-二氯辛酸乙酯的化学合成方法,2010.03.10,中国,ZL200710156217.1

  10. 苏为科,李坚军,王博,李佳,章莹,蔡继平,一种双(2-氯乙烷砜基)甲烷化合物的合成方法,2009.09.09,中国,ZL200710067350.X

  11. 于洪巍,王丹,王珏,王博,刘敏,磁性共价固定化酶载体的制备方法,2013.04.24,中国,ZL201110201473.4

  12. 苏为科,陈志卫,王博,一种1-氯辛烷的合成方法,2008.09.03,中国,ZL200610053703.6

  13. 苏为科,陈志卫,楼芳彪,徐园芬,王博,一种3-氯-1,2-苯并异噻唑类化合物的合成方法,2008.05.14,中国,ZL200610050843.8

讲授课程

化学工艺学(本科),生物催化(本科),高等分离工程(硕士),高等生物化工(博士)。

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